IgG anti-GM1 antibodies from patients with acute motor neuropathy are predominantly of the IgG1 and IgG3 subclasses Academic Article Article uri icon

Overview

MeSH Major

  • Antibodies, Anti-Idiotypic
  • Gangliosides
  • Immunoglobulin M
  • Myelin-Associated Glycoprotein

abstract

  • Increased titers of IgG anti-GM1 and anti-asialo GM1 (GA1) ganglioside antibodies are present in some patients with the Guillain-BarrĂ© syndrome, particularly with the motor axonal variant, and following infection with Campylobacter jejuni or parenteral administration of gangliosides. The subclass distribution of IgG anti-GM1 or GA1 antibodies from 19 patients with acute motor neuropathy and elevated antibody titers were measured by ELISA using mouse monoclonal antibodies specific for human IgG subclasses. The anti-GM1 or GA1 antibodies were predominantly of the IgG1 and IgG3 subclasses, which are capable of complement fixation, and are characteristic of a T cell-dependent antibody response.

publication date

  • January 1995

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/0165-5728(94)00190-Y

PubMed ID

  • 7730449

Additional Document Info

start page

  • 77

end page

  • 80

volume

  • 58

number

  • 1