Cerebrospinal fluid levels of kynurenine pathway metabolites in patients with eating disorders: relation to clinical and biochemical variable. Academic Article uri icon

Overview

MeSH

  • Adolescent
  • Adult
  • Body Weight
  • Brain
  • Female
  • Humans
  • Hydroxyindoleacetic Acid
  • Kynurenic Acid
  • Quinolinic Acid
  • Thinness
  • Tryptophan

MeSH Major

  • Anorexia Nervosa
  • Bulimia
  • Kynurenine

abstract

  • In brain, most L-tryptophan is metabolized to indoleamines, whereas in systemic tissues L-tryptophan is catabolized to kynurenine pathway metabolites. Among these latter compounds are: quinolinic acid, an N-methyl-D-aspartate receptor agonist; kynurenic acid, an antagonist of excitatory amino acid receptors that also reduces quinolinic acid-mediated neurotoxicity; and L-kynurenine, a possible convulsant. Because the metabolism of L-tryptophan through the kynurenine pathway is dependent upon adequate nutrition, we sought to determine whether the impaired nutrition characteristic of eating-disordered patients might be associated with specific disturbances in this metabolic pathway. Cerebrospinal fluid levels of L-tryptophan, quinolinic acid, kynurenic acid, L-kynurenine, and 5-hydroxyindoleacetic acid were measured in medication-free female patients meeting DSM-III-R criteria for either anorexia nervosa (n = 10) or normal-weight bulimia nervosa (n = 22), studied at varying stages of nutritional recovery. Eight healthy, normal-weight females served as a comparison group. Cerebrospinal fluid levels of kynurenic acid were significantly reduced in underweight anorectics, compared to normal females, but returned to normal values with restoration of normal body weight. Although cerebrospinal fluid quinolinic acid levels were not different from controls, the ratio of quinolinic acid to kynurenic acid was significantly increased during the underweight phase of anorexia nervosa. Furthermore, in the eating-disordered patients, kynurenic acid levels in cerebrospinal fluid correlated positively with percent-of-population average body weight.(ABSTRACT TRUNCATED AT 250 WORDS)

publication date

  • April 15, 1995

has subject area

  • Adolescent
  • Adult
  • Anorexia Nervosa
  • Body Weight
  • Brain
  • Bulimia
  • Female
  • Humans
  • Hydroxyindoleacetic Acid
  • Kynurenic Acid
  • Kynurenine
  • Quinolinic Acid
  • Thinness
  • Tryptophan

Research

keywords

  • Journal Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/0006-3223(94)00173-Z

PubMed ID

  • 7542489

Additional Document Info

start page

  • 512

end page

  • 520

volume

  • 37

number

  • 8