Transfer of genes to humans: early lessons and obstacles to success. Review uri icon

Overview

MeSH

  • Adenoviridae
  • Animals
  • Clinical Trials as Topic
  • Forecasting
  • Genetic Markers
  • Genetic Techniques
  • Genetic Vectors
  • Humans
  • Retroviridae

MeSH Major

  • Gene Transfer Techniques
  • Genetic Therapy

abstract

  • Enough information has been gained from clinical trials to allow the conclusion that human gene transfer is feasible, can evoke biologic responses that are relevant to human disease, and can provide important insights into human biology. Adverse events have been uncommon and have been related to the gene delivery strategies, not to the genetic material being transferred. Human gene transfer still faces significant hurdles before it becomes an established therapeutic strategy. However, its accomplishments to date are impressive, and the logic of the potential usefulness of this clinical paradigm continues to be compelling.

publication date

  • October 20, 1995

has subject area

  • Adenoviridae
  • Animals
  • Clinical Trials as Topic
  • Forecasting
  • Gene Transfer Techniques
  • Genetic Markers
  • Genetic Techniques
  • Genetic Therapy
  • Genetic Vectors
  • Humans
  • Retroviridae

Research

keywords

  • Journal Article
  • Review

Identity

Language

  • eng

PubMed ID

  • 7569994

Additional Document Info

start page

  • 404

end page

  • 410

volume

  • 270

number

  • 5235