Regulation of electrolyte transport with IL-1β in rabbit distal colon Academic Article uri icon


MeSH Major

  • Adenocarcinoma
  • Adenoma
  • Colonic Polyps
  • Inflammatory Bowel Diseases
  • Intestinal Neoplasms
  • Precancerous Conditions


  • Interletrkin-1beta levels are elevated in inflammatory bowel disease. In this study the mechanism by which interleukin-1beta affects electrolyte transport in the rabbit distal colon, was investigated. Interleukin-1beta caused a delayed increase in short-circuit current (I(sc)) which was attributed to protein synthesis since the effect was inhibited by cycloheximide. The interleukin-1beta induced increase in I(sc) was not affected by amiloride treatment but was completely inhibited by bumetanide or in chloride-free buffer and by indomethacin. Prostaglandin E(2) levels increased in tissue treated with interleukin-1beta, but this increase was reversed by cycloheximide. These data suggest that interleukin-1beta causes its effect via a yet to be identified second messenger, by increasing chloride secretion through a prostaglandin E(2) mediated mechanism.

publication date

  • January 1995



  • Academic Article



  • eng

PubMed Central ID

  • PMC2365610

Digital Object Identifier (DOI)

  • 10.1155/S0962935195000111

PubMed ID

  • 18475618

Additional Document Info

start page

  • 61

end page

  • 6


  • 4


  • 1