An astrocytic binding site for neuronal Thy-1 and its effect on neurite outgrowth Academic Article Article uri icon

Overview

MeSH Major

  • Brain
  • Carotid Stenosis
  • Cerebrovascular Circulation
  • Stroke

abstract

  • Thy-1, a member of the immunoglobulin superfamily, is one of the most abundant glycoproteins on mammalian neurons. Nevertheless, its role in the peripheral or central nervous system is poorly understood. Certain monoclonal antibodies to Thy-1 promote neurite outgrowth by rodent central nervous system neurons in vitro, suggesting that Thy-1 functions, in part, by modulating neurite outgrowth. We describe a binding site for Thy-1 on astrocytes. This Thy-1-binding protein has been characterized by immunofluroesence with specific anti-idiotype monoclonal antibodies and by three competitive binding assays using (i) anti-idiotype antibodies, (ii) purified Thy-1, and (iii) Thy-1-transfected cells. The Thy-1-binding protein may participate in axonal or dendritic development in the nervous system.

publication date

  • November 21, 1995

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1073/pnas.92.24.11195

PubMed ID

  • 7479964

Additional Document Info

start page

  • 11195

end page

  • 9

volume

  • 92

number

  • 24