P-glycoprotein – a marker of cancer-cell behavior Editorial Article uri icon


MeSH Major

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Drug Resistance, Multiple
  • Drug Resistance, Neoplasm
  • Neoplasms


  • Resistance to a broad array of cytotoxic drugs – multidrug resistance – is thought to be a major reason chemotherapy fails to cure most cancers. Multidrug resistance has been studied intensively since the human MDR1 gene was identified almost 10 years ago.1 Increased levels of the MDR1 product, called P-glycoprotein, are often associated in vitro with reduced intracellular concentrations of several anticancer drugs derived from plants, such as anthracyclines (e.g., doxorubicin), epipodophyllotoxins (e.g., etoposide), vinca alkaloids (e.g., vincristine), dactinomycin, and paclitaxel. When cells are grown in increasing concentrations of one of these cytotoxic drugs, populations of cells that overexpress the. © 1995, Massachusetts Medical Society. All rights reserved.

publication date

  • November 23, 1995



  • Editorial



  • eng

Digital Object Identifier (DOI)

  • 10.1056/NEJM199511233332111

PubMed ID

  • 7477126

Additional Document Info

start page

  • 1417

end page

  • 9


  • 333


  • 21