Abdominal multivisceral transplantation Academic Article uri icon

Overview

MeSH Major

  • Digestive System Surgical Procedures
  • Intestines
  • Viscera

abstract

  • Under FK506-based immunosuppression, 13 abdominal multivisceral transplantations were performed in 6 children and 7 adults. Of the 13 recipients, 7 (53.8%) are alive and well with functioning grafts after 9 to 31 months. Six recipients died: three from PTLD, one from rejection, one from sepsis, and one from respiratory failure. In addition to rejection, postoperative complications occurring in more than isolated cases included PTLD (n = 6), abdominal abscess formation (n = 5), pancreatitis (n = 3), and ampullary dysfunction (n = 2). In addition, infection by enteric microorganisms was common during the early postoperative period. Currently, all 7 survivors are on an oral diet and have normal liver function. Two recipients (one insulin-dependent) require antidiabetes treatment, in one case following distal pancreatectomy and in the other after two episodes of pancreatic rejection. Thus, abdominal multivisceral transplantation is a difficult but feasible operation that demands complex and prolonged posttransplantation management. It is not yet ready for application and awaits a better strategy of immune modulation.

publication date

  • February 3, 1995

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2953264

PubMed ID

  • 7530873

Additional Document Info

start page

  • 234

end page

  • 40

volume

  • 59

number

  • 2