A Collaborative Survey of 80 Mutations in the BRCA1 Breast and Ovarian Cancer Susceptibility Gene: Implications for Presymptomatic Testing and Screening Academic Article Article uri icon

Overview

MeSH Major

  • Algorithms
  • Fetal Growth Retardation
  • Image Enhancement
  • Image Interpretation, Computer-Assisted
  • Infant, Small for Gestational Age
  • Ultrasonography, Prenatal

abstract

  • The high frequency of protein-terminating mutations and the observation of many recurrent mutations found in a diverse set of samples could lead to a relatively simple diagnostic test for BRCA1 mutations. More data must be accumulated to address specifically the sensitivity and specificity of such a diagnostic testing procedure and to better estimate the age-specific risk for breast and ovarian cancer associated with such mutations.

authors

publication date

  • January 1995

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1001/jama.1995.03520310033026

PubMed ID

  • 7837387

Additional Document Info

start page

  • 535

end page

  • 41

volume

  • 273

number

  • 7