Jak-STAT signaling induced by the v-abl oncogene Academic Article uri icon

Overview

MeSH Major

  • B-Lymphocytes
  • Genes, abl
  • Milk Proteins
  • Protein-Tyrosine Kinases
  • Signal Transduction
  • Trans-Activators

abstract

  • The effect of the v-abl oncogene of the Abelson murine leukemia virus (A-MuLV) on the Jak-STAT pathway of cytokine signal transduction was investigated. In murine pre-B lymphocytes transformed with A-MuLV, the Janus kinases (Jaks) Jak1 and Jak3 exhibited constitutive tyrosine kinase activity, and the STAT proteins (signal transducers and activators of transcription) normally activated by interleukin-4 and interleukin-7 were tyrosine-phosphorylated in the absence of these cytokines. Coimmunoprecipitation experiments revealed that in these cells v-Abl was physically associated with Jak1 and Jak3. Inactivation of v-Abl tyrosine kinase in a pre-B cell line transformed with a temperature-sensitive mutant of v-abl resulted in abrogation of constitutive Jak-STAT signaling. A direct link may exist between transformation by v-abl and cytokine signal transduction.

publication date

  • December 1995

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 7569929

Additional Document Info

start page

  • 1875

end page

  • 7

volume

  • 269

number

  • 5232