Molecular assessment of histopathological staging in squamous-cell carcinoma of the head and neck Academic Article uri icon

Overview

MeSH Major

  • Carcinoma, Squamous Cell
  • Genes, p53
  • Head and Neck Neoplasms
  • Mutation

abstract

  • Among specimens initially believed to be negative by light microscopy, a substantial percentage of the surgical margins and lymph nodes from patients with squamous-cell carcinoma of the head and neck contained p53 mutations specific for the primary tumor. Patients with these positive margins appear to have a substantially increased risk of local recurrence. Molecular analysis of surgical margins and lymph nodes can augment standard histopathological assessment and may improve the prediction of local tumor recurrence.

publication date

  • January 1995

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1056/NEJM199502163320704

PubMed ID

  • 7619114

Additional Document Info

start page

  • 429

end page

  • 35

volume

  • 332

number

  • 7