Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma Academic Article uri icon

Overview

MeSH Major

  • Acquired Immunodeficiency Syndrome
  • DNA, Viral
  • Herpesviridae
  • Sarcoma, Kaposi

abstract

  • Representational difference analysis was used to isolate unique sequences present in more than 90 percent of Kaposi's sarcoma (KS) tissues obtained from patients with acquired immunodeficiency syndrome (AIDS). These sequences were not present in tissue DNA from non-AIDS patients, but were present in 15 percent of non-KS tissue DNA samples from AIDS patients. The sequences are homologous to, but distinct from, capsid and tegument protein genes of the Gammaherpesvirinae, herpesvirus saimiri and Epstein-Barr virus. These KS-associated herpesvirus-like (KSHV) sequences appear to define a new human herpesvirus.

publication date

  • December 1994

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 7997879

Additional Document Info

start page

  • 1865

end page

  • 9

volume

  • 266

number

  • 5192