The iron-responsive element binding protein: A target for synaptic actions of nitric oxide Academic Article Article uri icon


MeSH Major

  • Proteins
  • Ubiquitin


  • Molecular targets for the actions of nitric oxide (NO) have only been partially clarified. The dynamic properties of the iron-sulfur (Fe-S) cluster of the iron responsive-element binding protein (IRE-BP) suggested that it might serve as a target for NO produced in response to glutamatergic stimulation in neurons. In the present study, we demonstrate that N-methyl-D-aspartate, acting through NO, stimulates the RNA-binding function of the IRE-BP in brain slices while diminishing its aconitase activity. In addition, we demonstrate a selective localization of the IRE-BP in discrete neuronal structures, suggesting a potential role for this protein in the response of neurons to NO.

publication date

  • December 20, 1994



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1073/pnas.91.26.12994

PubMed ID

  • 7809162

Additional Document Info

start page

  • 12994

end page

  • 8


  • 91


  • 26