Chemical and mechanical degradation of UHMWPE: Report of the development of an in vitro test
Membrane Transport Proteins
Molecular Dynamics Simulation
The development of an in vitro test to examine the combined effects of chemical environment and cyclic loading history on the chemical, physical and mechanical properties of ultrahigh molecular weight polyethylene (UHMWPE), used in total joint replacement implants, is reported. The appropriate control and degrading environments were determined by maintaining gamma radiation sterilized UHMWPE for up to 6 months in aqueous environments of distilled water and three concentrations of hydrogen peroxide in distilled water. Specimens were evaluated by infrared spectroscopy.