Antibody targeting in metastatic colon cancer: A phase I study of monoclonal antibody F19 against a cell-surface protein of reactive tumor stromal fibroblasts Academic Article uri icon

Overview

MeSH Major

  • Antibodies, Monoclonal
  • Antigens, Neoplasm
  • Biomarkers, Tumor
  • Colonic Neoplasms
  • Fibroblasts
  • Growth Substances
  • Iodine Radioisotopes
  • Neoplasm Metastasis
  • Serine Endopeptidases

abstract

  • The FAP tumor fibroblast antigen is highly expressed in primary and metastatic colorectal carcinomas and shows limited expression in normal adult tissues. This highly selective expression pattern allows imaging of colorectal carcinoma lesions as small as 1 cm in diameter on 131I-mAbF19 scans. Because of the consistent presence of FAP in the stroma of epithelial cancers and the accessibility of FAP-positive tumor stromal fibroblasts to circulating monoclonal antibodies (mAbs), this study suggests possible diagnostic and therapeutic applications of humanized mAbF19 and mAbF19 constructs with novel immune and nonimmune effector functions.

publication date

  • June 1994

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 8201382

Additional Document Info

start page

  • 1193

end page

  • 203

volume

  • 12

number

  • 6