Selection criteria for breast conservation: The impact of young and old age and collagen vascular disease
Hemorrhagic Fevers, Viral
Multiplex Polymerase Chain Reaction
Preexisting collagen vascular disease is a contraindication for the use of breast-conserving radiation and surgery. Extremes of age must be considered in terms of recommending not so much a specific local regional treatment, but an overall strategy. For the very young patient with breast cancer, more aggressive systemic therapy should be considered in addition to the appropriate local regional therapy. For the elderly, preliminary pilot studies suggest that tamoxifen may play a role in local as well systemic control, perhaps opening the door for future trials examining the need for radiation in selected elderly patients.