Blood monocytes: Differing effector role in experimental visceral versus cutaneous leishmaniasis Article Report uri icon

Overview

MeSH Major

  • Antiprotozoal Agents
  • Developing Countries
  • Disease Outbreaks
  • Interferon-gamma
  • Leishmaniasis
  • Leishmaniasis, Visceral

abstract

  • Irrespective of the tissue infected or the strain involved, all Leishmania species selectively parasitize and replicate within the resident tissue macrophage. Henry Murray here discusses the role of a second mononuclear phagocyte, the blood monocyte, which is also attracted to leishmanial lesions, but which appears to play quite different roles in experimental visceral versus cutaneous infection: in visceral disease, the monocyte is a critical host defense effector cell, in cutaneous disease, it may, paradoxically, serve to perpetuate intracellular infection.

publication date

  • January 1994

Research

keywords

  • Report

Identity

Digital Object Identifier (DOI)

  • 10.1016/0169-4758(94)90117-1

PubMed ID

  • 15275451

Additional Document Info

start page

  • 220

end page

  • 3

volume

  • 10

number

  • 6