Enhanced endothelial adhesiveness in hypercholesterolemia is attenuated by L-arginine Academic Article uri icon

Overview

MeSH Major

  • Arginine
  • Endothelium, Vascular
  • Hypercholesterolemia
  • Nitric Oxide

abstract

  • Hypercholesterolemia enhances the adhesiveness of aortic endothelium for monocytes; this effect is attenuated by dietary L-arginine. Conversely, inhibition of NO synthesis enhances monocyte binding. The results suggest that endothelium-derived NO plays an important role in regulating the endothelial adhesiveness for monocytes. Alterations in NO activity may play a critical role in atherogenesis.

publication date

  • May 1994

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 8181143

Additional Document Info

start page

  • 2176

end page

  • 82

volume

  • 89

number

  • 5