Somatically mutated member of the human VλVIII gene family encodes anti-myelin-associated glycoprotein (MAG) activity Academic Article Article uri icon


MeSH Major

  • Antibodies, Anti-Idiotypic
  • Gangliosides
  • Immunoglobulin M
  • Myelin-Associated Glycoprotein


  • A highly conserved small family of human V lambda genes was identified by DNA homology to a V lambda gene isolated from a patient with demyelinating peripheral neuropathy, and which encodes an autoantibody with anti-MAG activity. Comparison of the genes indicates that the patient V lambda gene was derived from one of the germline genes. Together with published analyses of other anti-MAG IgM antibodies, which also appear to be mutated in comparison to known germline V genes, these results suggest that development of these pathogenic antibodies may reflect an antigen-driven, T cell-dependent process.

publication date

  • January 1994



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1016/0165-5728(94)90127-9

PubMed ID

  • 7512577

Additional Document Info

start page

  • 45

end page

  • 52


  • 51


  • 1