Randomized placebo-controlled trial of isotretinoin in chemoprevention of bronchial squamous metaplasia Academic Article uri icon

Overview

MeSH Major

  • Bronchi
  • Isotretinoin
  • Lung Neoplasms
  • Precancerous Conditions

abstract

  • Squamous metaplasia was frequently observed in bronchial biopsy samples from chronic smokers. From this study, we conclude that isotretinoin has no effect on squamous metaplasia, a potential intermediate end point of bronchial carcinogenesis. Although determining the exact role of isotretinoin in lung cancer prevention requires further study, the finding that there was a significant decrease in squamous metaplasia in the placebo group emphasizes the critical importance of a placebo-controlled study design in chemoprevention trials using intermediate end points.

publication date

  • May 1994

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 8164045

Additional Document Info

start page

  • 937

end page

  • 45

volume

  • 12

number

  • 5