Serum tumor marker decline is an early predictor of treatment outcome in germ cell tumor patients treated with cisplatin and ifosfamide salvage chemotherapy Academic Article Article uri icon


MeSH Major

  • Antineoplastic Combined Chemotherapy Protocols
  • Urinary Bladder Neoplasms


  • The rate of serum AFP and/or hCG decline during the first two cycles of therapy was predictive for event-free and overall survival in GCT patients treated with ifosfamide-based salvage therapy. Those patients with an appropriate serum tumor marker decline had a longer event-free and overall survival. When evaluated separately, the rate of hCG decline was more predictive of treatment outcome than decline of AFP. The rate of serum tumor marker regression during the first two cycles of therapy is a clinically useful tool in assessing treatment outcome at an early point in therapy and may thereby identify patients who could benefit from a change to more intensive therapy.

publication date

  • May 27, 1994



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1002/1097-0142(19940515)73:10<2520::AID-CNCR2820731012>3.0.CO;2-R

PubMed ID

  • 7513603

Additional Document Info

start page

  • 2520

end page

  • 6


  • 73


  • 10