Attenuation of the Neurotoxic Effect of Aβ Amyloid Peptide by Apolipoprotein E Academic Article uri icon

Overview

MeSH Major

  • Amyloid beta-Peptides
  • Apolipoproteins E
  • Hippocampus

abstract

  • Alzheimer's disease patients have increased frequency of apolipoprotein E allele c4, suggesting apoE4 is a risk factor determining disease. ApoE binds A beta amyloid peptide with great avidity in vitro and in the neuritic plaque. Potentially, binding of A beta to apolipoprotein E could increase A beta neurotoxicity. However, in hippocampal cultures, 0.1 microM apolipoprotein E eliminated the neurotoxicity of 10 microM A beta. Neuronal rescue was dose-dependent and occurred even after 48 hours exposure to A beta, but was overwhelmed by excess A beta. Thus, interaction between these proteins does not directly increase A beta neurotoxicity, and the role of ApoE in Alzheimer's disease remains to be elucidated.

publication date

  • February 28, 1994

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1006/bbrc.1994.1209

PubMed ID

  • 8123007

Additional Document Info

start page

  • 163

end page

  • 70

volume

  • 199

number

  • 1