Monoclonal IgM antibodies to GM1 and asialo-GM1 in chronic neuropathies cross-react with Campylobacter jejuni lipopolysaccharides Academic Article uri icon

Overview

MeSH Major

  • Antibodies, Monoclonal
  • Campylobacter jejuni
  • G(M1) Ganglioside
  • Immunoglobulin M
  • Lipopolysaccharides
  • Motor Neuron Disease
  • Paraproteinemias

abstract

  • We tested monoclonal IgM anti-GM1 and asialo-GM1 antibodies from 6 patients with chronic motor neuropathies for binding to lipopolysaccharides (LPS) from three stains of Campylobacter jejuni. Four of the 6 patients showed strong reactivity with LPS from at least one of the three C. jejuni strains tested as shown by enzyme-linked immunosorbent assay or western blot. Preabsorption with GM1 or asialo-GM1, or blocking with cholera toxin, prevented antibody binding to LPS. These studies indicate that human anti-GM1 or anti-asialo-GM1 antibodies cross-react with LPS from certain strains of C. jejuni, and that bacterial LPS might provide antigenic stimuli for the activation of B cells expressing anti-GM1 antibodies.

publication date

  • June 1994

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1002/ana.410350610

PubMed ID

  • 8210226

Additional Document Info

start page

  • 698

end page

  • 703

volume

  • 35

number

  • 6