Clinical and pharmacologic study of multidrug resistance reversal with vinblastine and bepridil Academic Article uri icon

Overview

MeSH Major

  • Antineoplastic Combined Chemotherapy Protocols
  • Carrier Proteins
  • Colorectal Neoplasms
  • Membrane Glycoproteins
  • Neoplasm Proteins

abstract

  • Bepridil plasma concentrations needed in vitro to modulate MDR could be achieved in this study with tolerable toxicity; however, despite most tumors being MDR1/Pgp-positive, no response was obtained that could be attributed to the drug combination. Mechanisms of drug resistance other than MDR are probably implicated in drug resistance of colorectal cancer.

publication date

  • January 1994

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1200/JCO.1994.12.4.812

PubMed ID

  • 7908691

Additional Document Info

start page

  • 812

end page

  • 9

volume

  • 12

number

  • 4