Immunolocalization of exoglycoproteins ('ependymins') in the goldfish brain Academic Article Article uri icon


MeSH Major

  • Nerve Regeneration
  • Optic Nerve
  • Proteins


  • Exoglycoproteins (X-GPs) are a group of very abundant soluble glycoproteins in the goldfish brain. Immunostaining with polyclonal antisera to X-GPs revealed consistent perinuclear staining in the cells of the inner and intermediate layers of the leptomeninx, which is homologous to the pia-arachnoid. Immunolabelling was also prominent in the outer wall of capillaries, and in a variable population of 10-12 microns granular cells that appeared mainly near the ventricles and occasionally within the ventricles or under the meninges. In some cases, small and medium-sized lymphocytes were immunostained. Lymphocytes were sometimes associated with the granular cells, which may be hematogenous cells in transit toward the ventricles. The choroid plexus, saccus dorsalis, the roof of the third ventricle and Reissner's fiber showed strong immunostaining. The localization of the X-GPs suggests that they may contribute to maintenance of the blood-brain barrier or to regulation of immune function within the brain.

publication date

  • November 23, 1994



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1007/BF00972469

PubMed ID

  • 7898609

Additional Document Info

start page

  • 1401

end page

  • 12


  • 19


  • 11