Cytokine expression in the placenta: The role of interleukin 1 and interleukin 1 receptor antagonist expression in chorioamnionitis and parturition Academic Article uri icon


MeSH Major

  • Chorioamnionitis
  • Cytokines
  • Interleukin-1
  • Labor, Obstetric
  • Placenta
  • Receptors, Interleukin-1


  • Interleukin 1 (IL-1) is known to be present in placental tissue and is implicated as an endogenous mediator of inflammation and parturition. This study was undertaken to assess the role of IL-1 receptor antagonist (IL-1ra) in the placenta. Placentas with acute chorioamnionitis, with meconium staining, and without significant inflammation were examined for immunohistochemical expression of IL-1 and IL-1ra. Interleukin 1 and IL-1ra immunoreactivity was variably noted in the amnion, trophoblast, vascular smooth muscle, stromal cells, fibrinoid, and decidua in all placentas. Interleukin 1 immunoreactivity was less intense than IL-1ra immunoreactivity, and both were generally more intense in acute chorioamnionitis. Interleukin 1 receptor antagonist was detected (approximately 5 to 6 ng/mL) in the amniotic fluid of pregnant women at term. Colocalization of IL-1 and IL-1ra in normal and inflamed placentas suggests that the balance between these proinflammatory and anti-inflammatory mediators plays a role in parturition as well as in the pathogenesis of acute inflammation. An increase and/or imbalance in the IL-1 and IL-1ra expression associated with chorioamnionitis may precipitate preterm labor.

publication date

  • January 1994



  • Academic Article



  • eng

PubMed ID

  • 7506905

Additional Document Info

start page

  • 52

end page

  • 5


  • 118


  • 1