A phase I trial of intrahepatic Verapamil and doxorubicin. Regional therapy to overcome multidrug resistance Academic Article Article uri icon

Overview

MeSH Major

  • Mycosis Fungoides
  • Sezary Syndrome

abstract

  • Based on estimations of normal hepatic artery blood flow, the estimated concentration of verapamil delivered to the hepatic tumors at 1.0 mg/kg/hour is 3.6 micrograms/ml (7.3 microM), which is comparable to concentrations at which an in vitro reversal of MDR is seen. This study demonstrates that the systemic toxicities of an MDR reversal agent can be overcome by regional drug delivery, establishing this approach as an important model system for further study of MDR modulation.

publication date

  • January 1994

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1002/1097-0142(19941115)74:10<2757::AID-CNCR2820741004>3.0.CO;2-O

PubMed ID

  • 7954234

Additional Document Info

start page

  • 2757

end page

  • 64

volume

  • 74

number

  • 10