Effect of sodium chloride supplementation on urinary endothelin-1 excretion in premature infants. Academic Article Article uri icon

Overview

MeSH

  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Time Factors
  • Weight Gain

MeSH Major

  • Endothelins
  • Food, Fortified
  • Infant Food
  • Infant, Premature
  • Sodium Chloride, Dietary

abstract

  • We investigated the role of endothelin-1 in the renal adaptation to alterations in sodium balance in premature infants. The postnatal course of urinary endothelin-1 excretion, an estimate of renal endothelin-1 production, was compared in premature infants receiving low or high sodium intake. Sodium supplementation was given in a dose of 3 to 5 mmol/kg per day and 1.5 to 2.5 mmol/kg per day at the postnatal ages of 8 to 21 and 22 to 35 days, respectively. Sodium balance and urinary endothelin-1 excretion were determined weekly up to the fifth week of life. Urinary endothelin-1 concentration (expressed in picomoles per liter) and urinary endothelin-1 excretion (expressed either in terms of picomoles per square meter per day or picomoles per millimole creatinine) were significantly lower in infants receiving a high sodium intake compared with those receiving low sodium intake (p < 0.001) in weeks 2 through 5. We conclude that in sodium-depleted premature infants with high urinary sodium excretion, an angiotensin II-mediated increase in renal endothelin-1 production occurs, which acts in concert with angiotensin II to restore sodium balance.

publication date

  • November 1994

has subject area

  • Endothelins
  • Food, Fortified
  • Humans
  • Infant
  • Infant Food
  • Infant, Newborn
  • Infant, Premature
  • Male
  • Sodium Chloride, Dietary
  • Time Factors
  • Weight Gain

Research

keywords

  • Comparative Study
  • Journal Article

Identity

Language

  • eng

PubMed ID

  • 7965436

Additional Document Info

start page

  • 793

end page

  • 797

volume

  • 125

number

  • 5 Pt 1