Indirect angiogenic cytokines upregulate VEGF and bFGF gene expression in vascular smooth muscle cells, whereas hypoxia upregulates VEGF expression only Academic Article uri icon

Overview

MeSH Major

  • Endothelial Growth Factors
  • Fibroblast Growth Factor 2
  • Lymphokines
  • Muscle, Smooth, Vascular
  • Platelet-Derived Growth Factor
  • RNA, Messenger
  • Transforming Growth Factor beta

abstract

  • These results indicate that certain indirect angiogenic cytokines, such as PDGF-BB or TGF-beta 1, may act via induction of bFGF and VEGF gene expression in cells resident near endothelial cells in vivo. Hypoxia constitutes a potent stimulus for VEGF gene expresion but does not regulate bFGF under the same experimental conditions.

publication date

  • August 1994

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 8044933

Additional Document Info

start page

  • 649

end page

  • 52

volume

  • 90

number

  • 2