Loss of Heterozygosity and Decreased Expression of NME Genes Correlate with Teratomatous Differentiation in Human Male Germ Cell Tumors Academic Article Article uri icon


MeSH Major

  • Ambulatory Care
  • Crowding
  • Hospitals, Public
  • Physician-Patient Relations
  • Quality of Health Care


  • Embryonal carcinoma in the human male is a pluripotential germ cell tumor (GCT), which is suggested to further differentiate to teratoma which displays somatic differentiation representing all three germinal layers. In a panel of 37 GCTs we determined frequency of loss of heterozygosity (LOH) and the level of expression of nucleoside diphosphate kinase (NDPK) genes NME 1 and NME 2. The frequency of LOH in teratomas (86%) was found to be highly significant (P < 0.01) compared to embryonal carcinomas (17%). We also found that the NME encoded proteins are expressed at a 4-5 fold lower level in teratomas compared to embryonal carcinomas. These findings lead us to hypothesize that a critical level of NDPK may be necessary for suppression of aberrant somatic differentiation.

publication date

  • July 29, 1994



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1006/bbrc.1994.2041

PubMed ID

  • 8048923

Additional Document Info

start page

  • 1096

end page

  • 103


  • 202


  • 2