Neoadjuvant hormonal therapy improves the therapeutic ratio in patients with bulky prostatic cancer treated with three-dimensional conformal radiation therapy Academic Article Article uri icon


MeSH Major

  • Prostatic Neoplasms


  • Neoadjuvant hormonal therapy is an effective method for decreasing the size of bulky prostatic tumors as well as for optimizing the geometry of the target volume in relation to the adjacent normal tissue structures prior to radiation therapy. Such an approach allows for reduction of the volume of normal tissues exposed to high doses in the majority of treated patients. Currently, studies are underway to determine whether NHT will lead to a decreased likelihood of long-term complications associated with radiotherapy of bulky, geometrically unfavorable prostatic tumors, and permit the safe delivery of escalated dose levels using conformal treatment techniques.

publication date

  • July 1994



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1016/0360-3016(94)90563-0

PubMed ID

  • 8040021

Additional Document Info

start page

  • 755

end page

  • 61


  • 29


  • 4