Patterns of failure following surgical resection of renal cell carcinoma: Implications for adjuvant local and systemic therapy
Carcinoma, Renal Cell
LF is rare following surgical management of RCC, and shows no clear causal relationship with the development of DM. Patients die of DM, and not LF. These data do not support the role of adjuvant radiation therapy in this disease. Patients with LN involvement or renal vein extension have a significantly increased risk for developing DM, and are therefore appropriate candidates for trials investigating systemic therapy.