Evaluation of delayed treatment of focal cerebral ischemia with three selective k-opioid agonists in cats Academic Article uri icon

Overview

MeSH Major

  • Analgesics
  • Benzeneacetamides
  • Dynorphins
  • Ischemic Attack, Transient
  • Pyrrolidines
  • Tetrahydronaphthalenes

abstract

  • Compounds that act at the kappa subclass of opiate receptors are effective in increasing survival, improving neurological function, and decreasing tissue damage and edema in a cat model of focal cerebral ischemia. The current study provides support for the benefits of treatment of acute cerebrovascular ischemia with kappa-opioid agonists. The agents may prove to be of superior clinical utility because of efficacy even when administered 6 hours after the onset of stroke.

publication date

  • January 1994

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 7916503

Additional Document Info

start page

  • 2047

end page

  • 53; discussion 2054

volume

  • 25

number

  • 10