The metabolic effects of platelet-activating factor antagonism in endotoxemic man Academic Article uri icon

Overview

MeSH Major

  • Cytokines
  • Endotoxins
  • Phenanthridines
  • Platelet Activating Factor
  • Toxemia
  • Triazines

abstract

  • These findings in the face of unaltered circulating cytokines tumor necrosis factor alpha, interleukin 1 beta, and interleukin 6, as well as the tumor necrosis factor receptor-I s, suggest that PAF may influence some endotoxin-induced, counterregulatory hormonal responses and symptoms through cytokine-independent mechanisms. This study further supports the role of PAF antagonists as an adjunct to cytokine blockade in the treatment of gram-negative sepsis.

publication date

  • January 1994

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 8279943

Additional Document Info

start page

  • 72

end page

  • 9

volume

  • 129

number

  • 1