In vivo muscle activity and epithelial function in the rabbit distal colon during experimental colitis Academic Article uri icon


MeSH Major

  • Cardiovascular Diseases
  • Indians, North American


  • Abstract The present in vivo study was conducted to investigate contractile activity and epithelial electrolyte transport in an inflammatory state during experimental colitis in the rabbit. Intrarectal administration of trinitrobenzenesulphonic acid (TNBS) induced a colitis‐like inflammation in the distal colon. Under basal conditions, TNBS evoked irregular patterns of contractions in 40% of treated animals, but total contractility and transmural potential difference were not significantly altered by this treatment. Contractile activity and transmural potential difference were increased by luminal perfusion with phosphate buffered saline in control, but not in TNBS‐treated animals. It was concluded that the inflamed colon does not respond normally to luminal stimulation and that this may contribute to the pathophysiology of inflammatory bowel disease (IBD). Copyright © 1994, Wiley Blackwell. All rights reserved

publication date

  • January 1994



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1111/j.1365-2982.1994.tb00195.x

Additional Document Info

start page

  • 289

end page

  • 294


  • 6


  • 4