Pharmacologic-guided trial of sequential methotrexate and thioguanine in children with advanced malignancies
Antineoplastic Combined Chemotherapy Protocols
Encouraging antitumor effects were produced with this regimen in heavily pretreated patients with lymphoma, particularly Hodgkin's disease (HD). The durations of responses were 17, 13+, 12, 9, and 7+ months. A phase II trial of the MTX/6-TG combination is warranted for the treatment of relapsed lymphoma.