Identification of genetic lesions associated with diffuse large-cell lymphoma Review uri icon

Overview

MeSH Major

  • Lymphoma, Large B-Cell, Diffuse

abstract

  • These results indicate that inactivation of the p53 tumor-suppressor gene may complement bcl-2 activation and be involved in the transformation of FL into DLLC. Activation of the bcl-6 oncogene may represent one of the steps in the pathogenesis of 'de novo' DLLC. Both lesions should prove useful as diagnostic and prognostic markers in the clinical management of these tumors.

publication date

  • January 1994

Research

keywords

  • Review

Identity

Language

  • eng

PubMed ID

  • 8172819

Additional Document Info

start page

  • 55

end page

  • 60

volume

  • 5

number

  • SUPPL. 1