Characterization of the promoter region of the gene for the rat neutral and basic amino acid transporter and chromosomal localization of the human gene Academic Article uri icon

Overview

MeSH Major

  • Phospholipid Transfer Proteins

abstract

  • The promoter region of the rat kidney neutral and basic amino acid transporter (NBAT) gene has been isolated and sequenced. The major transcription initiation site was mapped by primer extension. The entire promoter region and a set of 5' deletions within it were expressed at a high level in LLC-PK1 cells using the luciferase indicator gene. Positive and negative regulatory elements in the promoter region were observed. A human genomic clone of the transporter was also obtained and was used to localize the NBAT gene at the p21 region of chromosome 2.

publication date

  • August 2, 1994

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1073/pnas.91.16.7548

Additional Document Info

start page

  • 7548

end page

  • 52

volume

  • 91

number

  • 16