All-trans retinoic acid for acute promyelocytic leukemia: Results of the New York study Academic Article uri icon

Overview

MeSH Major

  • Leukemia, Promyelocytic, Acute
  • Tretinoin

abstract

  • All-trans retinoic acid is an effective agent to induce remission in patients with a molecular diagnosis of acute promyelocytic leukemia, but remissions are short and resistance develops rapidly. Although the incidence of early death was not reduced, the use of all-trans retinoic acid to induce remission, followed by cytotoxic chemotherapy for "consolidation," was associated with longer survival times when compared with historical controls treated only with chemotherapy. Additional studies to prevent or mitigate consequences of the "retinoic acid syndrome" and to identify specific patients who might benefit from earlier intervention with chemotherapy are needed to maximize the advantages of this approach.

publication date

  • February 15, 1994

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 8291820

Additional Document Info

start page

  • 278

end page

  • 86

volume

  • 120

number

  • 4