Hepatic arterial floxuridine and leucovorin for unresectable liver metastases from colorectal carcinoma: New dose schedules and survival update Academic Article uri icon

Overview

MeSH Major

  • Antineoplastic Combined Chemotherapy Protocols
  • Carcinoma
  • Colorectal Neoplasms
  • Floxuridine
  • Leucovorin
  • Liver Neoplasms

abstract

  • Hepatic arterial chemotherapy with FUDR and leucovorin for patients with hepatic metastases from colorectal carcinoma yields a high response rate and 1- and 2-year survivals of 86% and 62%, respectively. Although a lower dose of leucovorin (15 mg/m2) with FUDR produces a high response rate with less toxicity, before larger scale trials are initiated, further investigation is needed to reduce toxicity. A study of hepatic arterial dexamethasone with FUDR and leucovorin has been initiated for this purpose.

publication date

  • March 4, 1994

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 8313315

Additional Document Info

start page

  • 1134

end page

  • 42

volume

  • 73

number

  • 4