Frequency of apoptotic bodies positively correlates with Gleason grade in prostate cancer Academic Article Article uri icon


MeSH Major

  • Adenocarcinoma
  • Carcinoma, Squamous Cell
  • Carcinoma, Transitional Cell
  • Neoplasms, Multiple Primary
  • Urologic Neoplasms


  • Tissue samples from patients with carcinoma of the prostate of various Gleason grades were examined for the frequency of apoptotic bodies. Apoptotic bodies were scored by morphometric methods using hematoxylin-eosin (HE)-stained sections from surgical specimens of prostate cancer. Non-neoplastic prostate tissue adjacent to foci of cancer showed a very low frequency of apoptotic bodies. Significantly larger numbers of apoptotic bodies were observed in the areas of carcinoma than in the non-neoplastic control tissues, regardless of Gleason grade. Interestingly, a positive correlation was noted between apoptotic bodies and increasing Gleason grade. The positive correlation suggests that increased programmed cell death is a feature of the increasing malignant potential that is associated with higher Gleason grade in prostate cancer.

publication date

  • January 1994



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1016/0046-8177(94)90249-6

PubMed ID

  • 7520020

Additional Document Info

start page

  • 797

end page

  • 801


  • 25


  • 8