Immunohistochemical detection of bone morphogenetic proteins in bone and soft-tissue sarcomas Academic Article Article uri icon


MeSH Major

  • Biopsy, Needle
  • Evidence-Based Medicine
  • Neoplasm Invasiveness
  • Soft Tissue Neoplasms


  • Bone morphogenetic protein is expressed in a subset of osteosarcomas, a high proportion of MFHs of bone and soft tissue, and in spindle cell chondrosarcomas. In these tumors, BMP is localized predominantly to the cytoplasm of malignant cells with primitive mesenchymal features; no or little BMP is detected in the more differentiated elements of bone and soft tissue sarcomas. Different histologic types of bone and soft tissue sarcomas may mimic discrete stages of mesenchymal differentiation as defined by BMP expression and histologic criteria.

publication date

  • August 4, 1994



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1002/1097-0142(19940801)74:3<842::AID-CNCR2820740309>3.0.CO;2-B

PubMed ID

  • 8039112

Additional Document Info

start page

  • 842

end page

  • 7


  • 74


  • 3 SUPPL.