Interaction of shc with the ζ chain of the T cell receptor upon T cell activation Academic Article uri icon


MeSH Major

  • Adaptor Proteins, Signal Transducing
  • Lymphocyte Activation
  • Membrane Proteins
  • Oncogene Proteins
  • Receptors, Antigen, T-Cell
  • T-Lymphocytes


  • The shc oncogene product is tyrosine-phosphorylated by Src family kinases and after its phosphorylation interacts with the adapter protein Grb2 (growth factor receptor-bound protein 2). In turn, Grb2 interacts with the guanine nucleotide exchange factor for Ras, mSOS. Because several Src family kinases participate in T cell activation and Shc functions upstream of Ras, the role of Shc in T cell signaling was examined. Shc was phosphorylated on tyrosine after activation through the T cell receptor (TCR), and subsequently interacted with Grb2 and mSOS. The Src homology region 2 (SH2) domain of Shc directly interacted with the tyrosine-phosphorylated zeta chain of the TCR. Thus, Shc may couple TCR activation to the Ras signaling pathway.

publication date

  • November 5, 1993



  • Academic Article



  • eng

PubMed ID

  • 8235613

Additional Document Info

start page

  • 902

end page

  • 5


  • 262


  • 5135