Immune‐mediated thrombocytopenia secondary to suramin Academic Article Article uri icon

Overview

MeSH Major

  • Cell Differentiation
  • Embryonic Stem Cells
  • Endoderm
  • Hydrazones

abstract

  • The authors report a case of suramin-induced immune-mediated thrombocytopenia occurring in a patient on a Phase II protocol for treatment of metastatic renal cell carcinoma. On withdrawal of suramin, the acute and severe thrombocytopenia did not respond initially to plasmapheresis; subsequently, it resolved promptly and dramatically during the administration of intravenous gamma globulin, also coinciding with a decline in suramin blood levels. Results of immunologic and coagulation studies are reported and clinical implications discussed.

publication date

  • January 1993

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1002/1097-0142(19930201)71:3<851::AID-CNCR2820710331>3.0.CO;2-M

PubMed ID

  • 8431868

Additional Document Info

start page

  • 851

end page

  • 4

volume

  • 71

number

  • 3