Cortisol is transported by the multidrug resistance gene product P-glycoprotein Academic Article uri icon

Overview

MeSH Major

  • Hydrocortisone
  • Membrane Glycoproteins

abstract

  • The physiology of the multidrug transporter P-glycoprotein (Pgp) is still poorly understood. We now show evidence that cell lines with a high expression of Pgp display a reduced accumulation of cortisol and an ATP-dependent outward transport of the hormone. Cortisol efflux from Pgp negative cells does not have such an active component. Further we show that the steroid hormones cortisol, testosterone, and progesterone cause an immediate, dose-dependent increase of daunorubicin accumulation in Pgp overexpressing cells. These effects are particularly apparent for the more lipophilic steroids. These results demonstrate that Pgp may function as a transporter for cortisol and suggest a physiological role of the protein in steroid handling by organs such as the adrenal.

publication date

  • January 1993

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC1968171

Digital Object Identifier (DOI)

  • 10.1038/bjc.1993.54

PubMed ID

  • 8094292

Additional Document Info

start page

  • 284

end page

  • 9

volume

  • 67

number

  • 2