Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma Academic Article uri icon

Overview

MeSH Major

  • Lymphoma, Large B-Cell, Diffuse
  • Proto-Oncogenes
  • Zinc Fingers

abstract

  • The molecular pathogenesis of diffuse large-cell lymphoma (DLCL), the most frequent and clinically relevant type of lymphoma, is unknown. A gene was cloned from chromosomal translocations affecting band 3q27, which are common in DLCL. This gene, BCL-6, codes for a 79-kilodalton protein that is homologous with zinc finger-transcription factors. In 33 percent (13 of 39) of DLCL samples, but not in other types of lymphoid malignancies, the BCL-6 gene is truncated within its 5' noncoding sequences, suggesting that its expression is deregulated. Thus, BCL-6 may be a proto-oncogene specifically involved in the pathogenesis of DLCL.

publication date

  • December 1993

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 8235596

Additional Document Info

start page

  • 747

end page

  • 50

volume

  • 262

number

  • 5134