Uridine allows dose escalation of 5‐fluorouracil when given with N‐phosphonacetyl‐L‐Aspartate, methotrexate, and leucovorin Academic Article Article uri icon

Overview

MeSH Major

  • Acquired Immunodeficiency Syndrome

abstract

  • In the current regimen, uridine allowed dose escalation of 5-FU to 750 mg/m2, which some patients tolerated on a 3-week on, 1-week off schedule. Because of the vascular toxic effects associated with intravenous uridine, the authors recommend additional studies with oral uridine to determine whether the increase in 5-FU dose that uridine allows is associated with improved response rates.

publication date

  • January 1993

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1002/1097-0142(19930301)71:5<1875::AID-CNCR2820710526>3.0.CO;2-9

PubMed ID

  • 8448752

Additional Document Info

start page

  • 1875

end page

  • 81

volume

  • 71

number

  • 5