HIV-specific cytotoxic T-cell activity in an HIV-exposed but uninfected infant Academic Article uri icon

Overview

MeSH Major

  • HIV Infections
  • HIV Seropositivity
  • HIV-1
  • Pregnancy Complications, Infectious
  • T-Lymphocytes, Cytotoxic

abstract

  • The factors necessary for protective immunity against HIV-1 are unknown. Important information about these factors should come from study of people at high risk of HIV infection who have not apparently become infected. Among these are the estimated 60-85% of children who may be exposed in utero or perinatally to HIV-1 but do not become infected. We observed the transient appearance of HIV-specific cytotoxic T-lymphocyte (CTL) activity in a baby born to HIV-1-infected parents, in whom all standard markers of infection remained negative. These findings suggest that HIV-specific CTLs may be a marker for recently exposed, but uninfected, individuals.

publication date

  • April 3, 1993

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/0140-6736(93)93063-7

PubMed ID

  • 8096564

Additional Document Info

start page

  • 860

end page

  • 1

volume

  • 341

number

  • 8849