Motor neuron diseases and amyotrophic lateral sclerosis: GM1 antibodies and paraproteinemia Academic Article Article uri icon

Overview

MeSH Major

  • Antibodies, Anti-Idiotypic
  • Gangliosides
  • Immunoglobulin M
  • Myelin-Associated Glycoprotein

abstract

  • Six of 110 patients (5.5%) with forms of motor neuron disease had abnormal titers of GM1 antibodies of 1:1,600 or higher. Four others came with previously known high titers. Three patients with upper motor neuron (UMN) signs had titers of 1,600; those with probable or no UMN signs had higher titers. Nine patients had conduction block; six of them had abnormal antibody titers, four with 6,400 or higher. Therefore, patients with motor neuron disease and abnormal anti-GM1 titers may have UMN signs or conduction block.

publication date

  • February 1993

Research

keywords

  • Academic Article

Identity

PubMed ID

  • 8437712

Additional Document Info

start page

  • 418

end page

  • 20

volume

  • 43

number

  • 2