Granulocytic sarcoma is associated with the 8;21 translocation in acute myeloid leukemia Academic Article uri icon

Overview

MeSH Major

  • Chromosomes, Human, Pair 21
  • Chromosomes, Human, Pair 8
  • Leukemia, Myeloid
  • Translocation, Genetic

abstract

  • Our data suggest that this association is more common than generally recognized and may be specific. Patients with t(8;21) should be observed closely for signs and symptoms of granulocytic sarcoma. These patients may have a less favorable prognosis than other patients with t(8;21). Cooperative oncology groups should retrospectively identify patients with AML and t(8;21) who had a poor outcome to determine if they had a disproportionate incidence of granulocytic sarcoma. If so, aggressive therapy such as bone marrow transplantation may be warranted early in the therapeutic strategy.

publication date

  • January 1993

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 8478662

Additional Document Info

start page

  • 690

end page

  • 7

volume

  • 11

number

  • 4