Mediation by G proteins of signals that cause collapse of growth cones Academic Article uri icon

Overview

MeSH Major

  • Brain
  • GTP-Binding Proteins
  • Ganglia, Spinal
  • Neurons
  • Signal Transduction

abstract

  • During development, motion of nerve growth cones ceases on contact with particular targets. The signaling mechanism is unknown. In culture, growth cone collapse can be caused by solubilized embryonic brain membranes, central nervous system myelin, a 35-kilodalton protein isolated from myelin, and mastoparan. Collapse induced by each of these is blocked by pertussis toxin. Thus, collapse of growth cones is mediated by G protein-coupled receptors, which may be activated by proteins associated with the cell surface as well as by soluble ligands.

publication date

  • January 1993

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 8418498

Additional Document Info

start page

  • 77

end page

  • 9

volume

  • 259

number

  • 5091